The article “Adhesion of Mesenchymal Stem Cells to Glycated Collagen—Comparative Analysis of Dynamic and Static Conditions” has been published in Polymers – a leading scientific journal in the field of biomaterials and medical applications (a Q1 journal with a high impact factor).
The study reveals how mesenchymal stem cells interact with glycated collagen not only under standard laboratory (static) conditions, but also in a dynamic environment close to real conditions in the human body.
By using a microfluidic system and atomic force microscopy, the authors demonstrate that:
• cells attach extremely quickly (within minutes) to glycated collagen,
• but this adhesion is weaker and unstable over time,
• and glycation alters the mechanical and electrical properties of collagen in a way that compromises long-term cell–matrix interactions.
The results challenge established models of cell adhesion and are of major importance for regenerative medicine, tissue engineering, as well as for understanding processes in diabetes, cancer, and aging.
Congratulations to the broad interdisciplinary team from the Medical University of Pleven, the Bulgarian Academy of Sciences, Sofia University, and clinical partners for this contribution to contemporary biomedical science!
https://lnkd.in/dCGrpC_5
The scientific research is funded under project BG-RRP-2.004-0003-C01: “Research Higher School: Medical University – Pleven”, Strategic Research and Innovation Program for Development, funded by the European Union – NextGenerationEU, through the National Recovery and Resilience Plan of the Republic of Bulgaria.
